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Article

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

The Journal of pathology - 1 May 1999

Wang Z J, Ellis I, Zauber P, Iwama T, Marchese C, Talbot I, Xue W H, Yan Z Y, Tomlinson I

Abstract excerpt

Patients with Peutz-Jeghers' syndrome (PJS) develop hamartomatous gastrointestinal polyps and characteristic pigmentation, as a result of germline mutations in the LKB1 gene. The hamartomas in PJS were long considered to be without malignant potential. There is, however, accumulating epidemiological evidence to suggest that PJS predisposes to cancers at several different sites (colon, pancreas, breast, ovary,...

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Identifiers

PMID: 10398133
DOI: 10.1002/(SICI)1096-9896(199905)188:1<9::AID-PATH326>3.0.CO;2-E

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.PMID 10398133Read ↗

The hamartoma-adenoma-carcinoma sequenceSemantic proximity Read ↗

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.Semantic proximity Read ↗

Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome.Semantic proximity Read ↗

Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndromeSemantic proximity Read ↗

Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome.Semantic proximity Read ↗

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.Semantic proximity Read ↗

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.Semantic proximity Read ↗

Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.Semantic proximity Read ↗

Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma.Semantic proximity Read ↗

De novo germline mutation in the serine–threonine kinase STK11/LKB1 gene associated with Peutz–Jeghers syndromeSemantic proximity Read ↗

The molecular basis and clinical aspects of Peutz-Jeghers syndrome.Semantic proximity Read ↗

Peutz-Jeghers syndrome: risks of a hereditary condition.Semantic proximity Read ↗

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