Article
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Molecular cell - 1 Jun 2001
Karuman P, Gozani O, Odze R D, Zhou X C, Zhu H, Shaw R, Brien T P, Bozzuto C D, Ooi D, Cantley L C, Yuan J
Abstract excerpt
Here, we investigate the mechanism and function of LKB1, a Ser/Thr kinase mutated in Peutz-Jegher syndrome (PJS). We demonstrate that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. In vivo, LKB1 is highly upregulated in pyknotic intestinal...
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