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Article

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.

Gut - 1 Nov 2013

Beer Sebastian, Zhou Jiayi, Szabó András, Keiles Steven, Chandak Giriraj Ratan, Witt Heiko, Sahin-Tóth Miklós

Abstract excerpt

OBJECTIVE: The digestive enzyme chymotrypsin C (CTRC) protects against pancreatitis by promoting degradation of trypsinogen, thereby curtailing potentially harmful trypsinogen activation. Loss-of-function variants in CTRC increase the risk for chronic pancreatitis. The aim of the present study was to perform comprehensive functional analysis of all missense CTRC variants identified to date. DESIGN: We...

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Source

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Identifiers

PMID: 22942235
DOI: 10.1136/gutjnl-2012-303090
PMCID: PMC3660471

Genes

CTRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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