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Article

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

The Journal of biological chemistry - 10 Jul 2015

Szabó András, Ludwig Maren, Hegyi Eszter, Szépeová Renata, Witt Heiko, Sahin-Tóth Miklós

Abstract excerpt

Human chymotrypsin C (CTRC) protects against pancreatitis by degrading trypsinogen and thereby curtailing harmful intra-pancreatic trypsinogen activation. Loss-of-function mutations in CTRC increase the risk for chronic pancreatitis. Here we describe functional analysis of eight previously uncharacterized natural CTRC variants tested for potential defects in secretion, proteolytic stability, and catalytic...

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Source

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Identifiers

PMID: 26013824
DOI: 10.1074/jbc.M114.618439
PMCID: PMC4498067

Genes

CTRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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