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The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

10 Dec 2008

Abstract excerpt

The human chymase (HC) is a major granule constituent of mast cells (MCs) residing in the connective tissue and the sub-mucosa. Although many potential substrates have been described for this important MC enzyme, its full range of in vivo substrates has most likely not yet been identified. A major step toward a better understanding of the function of the HC is therefore to determine its extended cleavage...

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PMID: 19073880
DOI: 10.1093/intimm/dxn128

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