Article
Concordance between HIV-1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.
HIV medicine - 1 Oct 2011
Verhofstede C, Brudney D, Reynaerts J, Vaira D, Fransen K, De Bel A, Seguin-Devaux C, De Wit S, Vandekerckhove L, Geretti A-M
Abstract excerpt
OBJECTIVE: The aim of the study was to evaluate the use of proviral DNA as a source of viral genetic material for genotypic coreceptor tropism testing (GTT). METHODS: GTT consisted of bulk V3 sequencing followed by geno2pheno interpretation with the interpretative cut-off [false positive rate (FPR)] set at 5 and 10%. GTT was performed for 165 patients with a viral load of >500 HIV-1 RNA copies/mL on...
Topics
- Algorithms
- DNA, Viral
- Gene Amplification
- Genotype
- HIV Infections
- HIV-1
- Humans
- Phenotype
- RNA, Viral
- Viral Load
- Viral Tropism
- Viremia