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Article

T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice.

Clinical immunology (Orlando, Fla.) - 1 Jun 2015

Gorelik Gabriela, Sawalha Amr H, Patel Dipak, Johnson Kent, Richardson Bruce

Abstract excerpt

Genetic and environmental factors contribute to the onset and progression of lupus. CD4+ T cells from patients with active lupus show a decreased ERK signaling pathway, which causes changes in gene expression. The defect points to its upstream regulator, PKCδ, which exhibits a deficient activity...

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Source

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Identifiers

PMID: 25829232
DOI: 10.1016/j.clim.2015.03.017
PMCID: PMC4464903

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25829232-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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