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Article

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Lin Xiaotian, Hamilton-Williams Emma E, Rainbow Daniel B, Hunter Kara M, Dai Yang D, Cheung Jocelyn, Peterson Laurence B, Wicker Linda S, Sherman Linda A

Abstract excerpt

In the NOD mouse model of type 1 diabetes, insulin-dependent diabetes (Idd) loci control the development of insulitis and diabetes. Independently, protective alleles of Idd3/Il2 or Idd5 are able to partially protect congenic NOD mice from insulitis and diabetes, and to partially tolerize islet-specific CD8(+) T cells. However, when the two regions are combined, mice are almost completely protected, strongly...

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Share to Cation Transport Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Glucose-6-Phosphatase

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Share to Islets of Langerhans

Share to Mice, Inbred NOD

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Source

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Identifiers

PMID: 23427248
DOI: 10.4049/jimmunol.1203422
PMCID: PMC3608810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.PMID 23427248Read ↗

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