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Article

Selective inhibition of repair of active genes by hyperthermia is due to inhibition of global and transcription coupled repair pathways.

Carcinogenesis - 1 Apr 1995

Sakkers R J, Filon A R, Brunsting J F, Kampinga H H, Konings A W, Mullenders L H

Abstract excerpt

Hyperthermia specifically inhibits the repair of UV-induced DNA photolesions in transcriptionally active genes. To define more precisely which mechanisms underlie the heat-induced inhibition of repair of active genes, removal of cyclobutane pyrimidine dimers (CPDs) was studied in human fibroblasts with different repair capacities and different transcriptional status of the adenosine deaminase gene, i.e. normal...

Topics

Adenosine Deaminase
Cell Line
DNA
DNA Damage
DNA Repair
Fibroblasts
Gene Expression Regulation
Humans
Hyperthermia, Induced
Phenotype
Pyrimidine Dimers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

Severe Combined Immunodeficiency

Transcription, Genetic

Ultraviolet Rays

Source

Identifiers

PMID: 7537181
DOI: 10.1093/carcin/16.4.743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7537181-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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