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Article

Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.

Molecular and cellular biology - 1 Mar 2004

Tian Ming, Jones David A, Smith Michele, Shinkura Reiko, Alt Frederick W

Abstract excerpt

Xeroderma pigmentosum (XP) is a human disorder which is characterized by hypersensitivity to sunlight and elevated incidence of skin cancer. The disease is caused by mutations in genes that encode components of the nucleotide excision repair pathway. The gene product of XP complementation group G...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14993263
DOI: 10.1128/MCB.24.6.2237-2242.2004
PMCID: PMC355871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14993263-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.PMID 14993263Read ↗

Conserved Residues of Human XPG Protein Important for Nuclease Activity and Function in Nucleotide Excision RepairSemantic proximity Read ↗

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The founding members of xeroderma pigmentosum group G produce XPG protein with severely impaired endonuclease activity.Semantic proximity Read ↗

A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function.Semantic proximity Read ↗

Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG DeficiencySemantic proximity Read ↗

Characterization of three XPG-defective patients identifies three missense mutations that impair repair and transcription.Semantic proximity Read ↗

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.Semantic proximity Read ↗

Xeroderma pigmentosum group G with severe neurological involvement and features of Cockayne syndrome in infancy.Semantic proximity Read ↗

UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency.Semantic proximity Read ↗

Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema.Semantic proximity Read ↗

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