Article
Clustered sites of DNA repair synthesis during early nucleotide excision repair in ultraviolet light-irradiated quiescent human fibroblasts.
Experimental cell research - 10 Jun 2002
Svetlova Maria, Solovjeva Lioudmila, Pleskach Nadezhda, Yartseva Natalia, Yakovleva Tatyana, Tomilin Nikolai, Hanawalt Philip
Abstract excerpt
The ubiquitous process of nucleotide excision repair includes an obligatory step of DNA repair synthesis (DRS) to fill the gapped heteroduplex following excision of a short (approximately 30-nucleotide) damaged single-strand fragment. Using 5-iododeoxyuridine to label repair patches during the first 10-60 min after UV irradiation of quiescent normal human fibroblasts we have visualized a limited number of...
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