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Article

p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.

Molecular and cellular biology - 1 Jul 1998

Hwang B J, Toering S, Francke U, Chu G

Abstract excerpt

A subset of xeroderma pigmentosum (XP) group E cells lack a factor that binds to DNA damaged by UV radiation. This factor can be purified to homogeneity as p125, a 125-kDa polypeptide. However, when cDNA encoding p125 is translated in vitro, only a small fraction binds to UV-damaged DNA, suggesti...

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Identifiers

PMID: 9632823
DOI: 10.1128/MCB.18.7.4391
PMCID: PMC109023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9632823-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.PMID 9632823Read ↗

The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription.Semantic proximity Read ↗

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Characterization of molecular defects in xeroderma pigmentosum group C.Semantic proximity Read ↗

Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype.Semantic proximity Read ↗

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