Article
DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice.
Molecular and cellular biology - 1 Jun 1991
Beecham E J, Mushinski J F, Shacter E, Potter M, Bohr V A
Abstract excerpt
This report describes an unexpected difference in the efficiency of removal of UV-induced DNA damage in the c-myc locus in splenic B lymphoblasts from two inbred strains of mice. In cells from plasmacytoma-resistant DBA/2N mice, 35% of UV-induced damage in the regulatory and 5' flank of c-myc is...
Topics
- Animals
- B-Lymphocytes
- Blotting, Northern
- DNA
- DNA Damage
- DNA Repair
- DNA Replication
- Genes, myc
- Genetic Predisposition to Disease
- Immunity, Innate
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Plasmacytoma
- Proto-Oncogenes
- RNA
- Restriction Mapping
- Tetrahydrofolate Dehydrogenase