Article
Induction of specific-locus and dominant lethal mutations in male mice in the low dose range by methyl methanesulfonate (MMS).
Mutation research - 1 May 1990
Ehling U H, Neuhäuser-Klaus A
Abstract excerpt
Methyl methanesulfonate (MMS) induces specific-locus and dominant lethal mutations in spermatozoa and spermatids of mice. A dose of 15 mg/kg b.w. of MMS induces 9% dominant lethal mutations in the most sensitive germ-cell stages, corresponding to the mating intervals 5-8 and 9-12 days post treatment. A dose of 150 mg/kg b.w. of MMS in the same mating intervals induces 100% dominant lethal mutations. The...
Topics
- Animals
- Dose-Response Relationship, Drug
- Female
- Genes, Dominant
- Genes, Lethal
- Homozygote
- Male
- Methyl Methanesulfonate
- Mice
- Mutation
- Spermatogenesis
- Spermatozoa