Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test.

Mutation research - 20 Sept 1998

Favor J

Abstract excerpt

Ethylnitrosourea is the most efficient chemical mutagen in spermatogonial stem cells of the mouse and its mutagenic activity has been intensively studied. The pertinent specific-locus mutation test results for a discussion of low dose-effect studies have been summarized and indicate: (1) A threshold dose response best characterizes the relationship between dose and mutation rate. (2) The reduced effectiveness of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Ethylnitrosourea
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C3H

Share to Mutagenicity Tests

Share to Mutagens

Share to Phenotype

Share to Spermatogonia

Source

Identifiers

PMID: 9748590
DOI: 10.1016/s0027-5107(98)00139-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test.PMID 9748590Read ↗

The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea.Semantic proximity Read ↗

A dose-response analysis of ethylnitrosourea-induced recessive specific-locus mutations in treated spermatogonia of the mouse.Semantic proximity Read ↗

Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.Semantic proximity Read ↗

Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test.Semantic proximity Read ↗

Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.Semantic proximity Read ↗

Differential Response of Mouse Male Germ-Cell Stages to Radiation-Induced Specific-Locus and Dominant MutationsSemantic proximity Read ↗

The effect of dose rate on the frequency of specific-locus mutations induced in mouse spermatogonia is restricted to larger lesions; a retrospective analysis of historical data.Semantic proximity Read ↗

Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse.Semantic proximity Read ↗

Unscheduled DNA synthesis assay in mammalian spermatogenic cells: an update.Semantic proximity Read ↗

The induction of forward and reverse specific-locus mutations and dominant cataract mutations in spermatogonia of treated strain DBA/2 mice by ethylnitrosourea.Semantic proximity Read ↗

The frequency of dominant cataract and recessive specific-locus mutations and mutation mosaics in F1 mice derived from post-spermatogonial treatment with ethylnitrosourea.Semantic proximity Read ↗

Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.