The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test.

doi:10.1016/s0027-5107(98)00139-0

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Article

The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test.

Mutation research - 20 Sept 1998

Favor J

Abstract excerpt

Ethylnitrosourea is the most efficient chemical mutagen in spermatogonial stem cells of the mouse and its mutagenic activity has been intensively studied. The pertinent specific-locus mutation test results for a discussion of low dose-effect studies have been summarized and indicate: (1) A thresh...

Topics

Animals
Dose-Response Relationship, Drug
Ethylnitrosourea
Male
Mice
Mice, Inbred C3H
Mutagenicity Tests
Mutagens
Phenotype
Spermatogonia

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