Article
Induction of specific-locus and dominant lethal mutations in male mice by busulfan.
Mutation research - 1 Aug 1991
Ehling U H, Neuhäuser-Klaus A
Abstract excerpt
The chemotherapeutic agent busulfan was tested for the induction of dominant lethal and specific-locus mutations in male mice. A dose of 5 mg/kg b.w. of busulfan induces dominant lethal mutations in spermatozoa. A dose of 20 mg/kg b.w. induces dominant lethal mutations in spermatozoa and spermatids. A total of 83,196 offspring were scored in the specific-locus experiments. Busulfan-induced specific-locus...
Topics
- Alleles
- Animals
- Busulfan
- Female
- Genes, Dominant
- Genes, Lethal
- Homozygote
- Male
- Mice
- Mutagenesis
- Spermatids
- Spermatozoa