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Article

Induction of specific-locus and dominant lethal mutations in male mice by 1-methyl-1-nitrosourea (MNU).

Mutation research - 1 Jan 2000

Ehling U H, Neuhäuser-Klaus A

Abstract excerpt

1-Methyl-1-nitrosourea (MNU) induced specific-locus mutations in mice in all spermatogenic stages except spermatozoa. After intraperitoneal injection of 70 mg/kg body weight of MNU a high yield of specific-locus mutations was observed in spermatids (21.8 x 10(-5) mutations per locus per gamete). The highest mutational yield was induced in differentiating spermatogonia. In 1594 offspring we observed 5...

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Identifiers

PMID: 1944358
DOI: 10.1016/0027-5107(91)90201-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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