Induction of specific-locus and dominant lethal mutations in male mice by 1-methyl-1-nitrosourea (MNU).

doi:10.1016/0027-5107(91)90201-x

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Article

Induction of specific-locus and dominant lethal mutations in male mice by 1-methyl-1-nitrosourea (MNU).

Mutation research - 1 Jan 2000

Ehling U H, Neuhäuser-Klaus A

Abstract excerpt

1-Methyl-1-nitrosourea (MNU) induced specific-locus mutations in mice in all spermatogenic stages except spermatozoa. After intraperitoneal injection of 70 mg/kg body weight of MNU a high yield of specific-locus mutations was observed in spermatids (21.8 x 10(-5) mutations per locus per gamete)....

Topics

Alleles
Animals
Female
Fertilization
Genes, Dominant
Genes, Lethal
Homozygote
Male
Methylnitrosourea
Mice
Mutation
Spermatogenesis

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