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Article

Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test.

Mutation research - 16 Jul 1999

Favor J

Abstract excerpt

Mouse germ cell specific locus mutagenesis data and a molecular characterization of mutant alleles have been reviewed to arrive at an understanding of the mechanism of mutation induction in mammals. (a) The spermatogenic stage specificity for the sensitivity to mutation induction by 20 chemical mutagens is considered. (b) The effects of a saturable repair process and its recovery over time are examined for the...

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Identifiers

PMID: 10517996
DOI: 10.1016/s1383-5742(99)00050-2

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