Article
Induction of specific-locus and dominant lethal mutations in male mice by ifosfamide (Holoxan).
Genetical research - 1 Dec 1998
Ehling U H, Favor J, Neuhäuser-Klaus A, Adler I D
Abstract excerpt
Ifosfamide induced dominant lethal mutations in spermatozoa of mice at doses of 200 and 300 mg/kg and in spermatids and spermatocytes at 600 mg/kg. The highest dose also induced specific-locus mutations in post-spermatogonial germ-cell stages of mice but not in spermatogonial stem cells. The nature of the induced mutations suggests they are intergenic. The spermatogenic specificity of ifosfamide in mouse germ...
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