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Article

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.

Annals of neurology - 1 Jul 2013

Liachko Nicole F, McMillan Pamela J, Guthrie Chris R, Bird Thomas D, Leverenz James B, Kraemer Brian C

Abstract excerpt

OBJECTIVE: Kinase hyperactivity occurs in both neurodegenerative disease and cancer. Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TDP-43 inclusions. Dual phosphorylation of TDP-43 at serines 409/410 (S409/410) drives neurotoxicity in disease models; therefore, TDP-43-specific kinases are candidate targets for...

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Identifiers

PMID: 23424178
DOI: 10.1002/ana.23870
PMCID: PMC3775949

Genes

CDC7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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