Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

Holbert Sébastien, Dedeoglu Alpaslan, Humbert Sandrine, Saudou Frédéric, Ferrante Robert J, Néri Christian

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine (polyQ) expansion in the protein huntingtin (htt). Pathogenesis in HD seems to involve the formation of neuronal intranuclear inclusions and the abnormal regulation of transcription and signal transduction. To identify previously uncharacterized htt-interacting proteins in a simple model system, we used a yeast two-hybrid screen with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Microtubule-Associated Proteins

Share to Minor Histocompatibility Antigens

Share to rho GTP-Binding Proteins

Share to Two-Hybrid System Techniques

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 12604778
DOI: 10.1073/pnas.0437967100
PMCID: PMC151406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.PMID 12604778Read ↗

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s DiseaseSemantic proximity Read ↗

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.Semantic proximity Read ↗

Multiple pathways contribute to the pathogenesis of Huntington disease.Semantic proximity Read ↗

In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies ARIH2 as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons.Semantic proximity Read ↗

Recent Advances in the Study of Huntingtin Interacting ProteinsSemantic proximity Read ↗

TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegansSemantic proximity Read ↗

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Semantic proximity Read ↗

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.Semantic proximity Read ↗

Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database.Semantic proximity Read ↗

Huntingtin interacts with a family of WW domain proteins.Semantic proximity Read ↗

HAP40 is a conserved central regulator of Huntingtin and a specific modulator of mutant Huntingtin toxicitySemantic proximity Read ↗

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.