Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression.

The Journal of steroid biochemistry and molecular biology - 1 Nov 2008

Roff Alanna, Wilson Robin Taylor

Abstract excerpt

The active form of vitamin D (1alpha,25(OH)(2)D(3)) is known to have antiproliferative effects and has been implicated in cancers of the colon, breast, and prostate. These cancers occur more frequently among African Americans than Caucasians, and individuals with African ancestry are known to have approximately twofold lower levels of serum vitamin D (25(OH)D) compared with individuals of European ancestry....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Calcitriol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Lymphocytes

Share to Steroid Hydroxylases

Share to Transcriptional Activation

Share to Vitamin D3 24-Hydroxylase

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 18824104
DOI: 10.1016/j.jsbmb.2008.08.009
PMCID: PMC2749287

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression.PMID 18824104Read ↗

CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.Semantic proximity Read ↗

A Downstream Intergenic Cluster of Regulatory Enhancers Contributes to the Induction of CYP24A1 Expression by 1α,25-Dihydroxyvitamin D3Semantic proximity Read ↗

Genetic Polymorphisms in Cytochrome P450 Enzymes Involved in Vitamin D Metabolism and the Vitamin D Receptor: Their Clinical RelevanceSemantic proximity Read ↗

Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer.Semantic proximity Read ↗

Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study.Semantic proximity Read ↗

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases.Semantic proximity Read ↗

Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis.Semantic proximity Read ↗

Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.Semantic proximity Read ↗

Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans.Semantic proximity Read ↗

The Role of Polymorphisms in Vitamin D-Related Genes in Response to Vitamin D Supplementation.Semantic proximity Read ↗

Genome-Wide Association Study of Serum 25-Hydroxyvitamin D in US WomenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.