Article
Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer.
Annual review of nutrition - 1 Jan 2009
McCullough Marjorie L, Bostick Roberd M, Mayo Tinisha L
Abstract excerpt
Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR's ligand, 1alpha,25-(OH)(2)-vitamin D. Herein we review the background and evidence to date on associations between polymorphisms in VDR and selected genes in the vitamin D pathway in relation to colorectal, breast, and...
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