Article
Increased homologous integration frequency in Yarrowia lipolytica strains defective in non-homologous end-joining.
Current genetics - 1 May 2013
Kretzschmar Anne, Otto Christina, Holz Martina, Werner Severine, Hübner Linda, Barth Gerold
Abstract excerpt
The ascomycetous yeast Yarrowia lipolytica has been established as model system for studies of several research topics as well as for biotechnological processes in the last two decades. However, frequency of heterologous recombination is high in this yeast species, and so knockouts of genes are laborious to achieve. Therefore, the aim of this study was to check whether a reduction of non-homologous end-joining...
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