Accelerating yeast adaptation: harnessing thermal stress for genomic diversification and thermotolerance in Yarrowia lipolytica.

Abstract excerpt

Temperature sensitivity remains a significant bottleneck in the industrial application of the oleaginous yeast Yarrowia lipolytica. While adaptive evolution and metabolic engineering have produced thermotolerant variants, the impact of thermal stress on the genomic integrity of this non-conventional yeast remains poorly understood. Here, we employed a mutation accumulation framework coupled with whole-genome...

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