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Article

The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice.

PloS one - 1 Jan 2013

Morgan Marc A J, Muller Pari S S, Mould Arne, Newland Stephen A, Nichols Jennifer, Robertson Elizabeth J, Cooke Anne, Bikoff Elizabeth K

Abstract excerpt

The spontaneous destruction of insulin producing pancreatic beta cells in non-obese diabetic (NOD) mice provides a valuable model of type 1 diabetes. As in humans, disease susceptibility is controlled by the classical MHC class II genes that guide CD4(+) T cell responses to self and foreign antigens. It has long been suspected that the dedicated class II chaperone designated HLA-DM in humans or H-2M in mice also...

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Share to Antigens, Differentiation, B-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

Share to Mice, Inbred NOD

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Source

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Identifiers

PMID: 23418596
DOI: 10.1371/journal.pone.0056738
PMCID: PMC3572069

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