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Article

Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.

International immunology - 1 Mar 2010

Brims Daniel R, Qian Jie, Jarchum Irene, Mikesh Leann, Palmieri Edith, Ramagopal Udupi A, Malashkevich Vladimir N, Chaparro Rodolfo J, Lund Torben, Hattori Masakazu, Shabanowitz Jeffrey, Hunt Donald F, Nathenson Stanley G, Almo Steven C, Dilorenzo Teresa P

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing pancreatic beta cells. In both humans and the non-obese diabetic (NOD) mouse model of T1D, class II MHC alleles are the primary determinant of disease susceptibility. However, class I...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20093428
DOI: 10.1093/intimm/dxp127
PMCID: PMC2829095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20093428-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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