Article
Osteopontin splice variants expressed by breast tumors regulate monocyte activation via MCP-1 and TGF-β1.
Cellular & molecular immunology - 1 Mar 2013
Sun Jintang, Feng Alei, Chen Songyu, Zhang Yun, Xie Qi, Yang Meixiang, Shao Qianqian, Liu Jia, Yang Qifeng, Kong Beihua, Qu Xun
Abstract excerpt
Osteopontin (OPN), a multifunctional glycoprotein, has three transcripts that have distinct roles in tumors in vitro. Whether OPN transcripts have different functions in tumor processes in vivo is unclear. It has been reported that immune cell-derived OPN can promote tumor formation. We propose a hypothesis that tumor-derived OPN may facilitate tumor immune escape by affecting immune cell differentiation and...
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