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Osteopontin-c Splicing Isoform Contributes to Ovarian Cancer Progression

25 Jan 2011

Abstract excerpt

Ovarian carcinoma is one of the most aggressive gynecological diseases and generally diagnosed at advanced stages. Osteopontin (OPN) is one of the proteins overexpressed in ovarian cancer and is involved in tumorigenesis and metastasis. Alternative splicing of OPN leads to 3 isoforms, OPNa, OPNb, and OPNc. However, the expression pattern and the roles of each of these isoforms have not been previously...

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PMID: 21263033
DOI: 10.1158/1541-7786.mcr-10-0463

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