Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection.

doi:10.1093/infdis/jiac349

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Article

Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection.

The Journal of infectious diseases - 1 Nov 2022

Santos Bravo Marta, Plault Nicolas, Sánchez-Palomino Sonsoles, Rodríguez Cristina, Navarro Gabriel Mireia, Mosquera María Mar, Fernández Avilés Francesc, Suarez-Lledó María, Rovira Montserrat, Bodro Marta, Moreno Asunción, Linares Laura, Cofan Frederic, Berengua Carla, Esteva Cristina, Cordero Elisa, Martin-Davila Pilar, Aranzamendi Maitane, Pérez Jiménez Ana Belén, Vidal Elisa, Fernández Sabé Nuria, Len Oscar, Hantz Sebastien, Alain Sophie, Marcos María Ángeles

Abstract excerpt

BACKGROUND: This study describes the genotypic and phenotypic characterization of novel human cytomegalovirus (HCMV) genetic variants of a cohort of 94 clinically resistant HCMV patients. METHODS AND RESULTS: Antiviral-resistant mutations were detected in the UL97, UL54, and UL56 target genes of 25 of 94 (26.6%) patients. The genotype-phenotype correlation study resolved the status of 5 uncharacterized UL54...

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PMID: 35993155
DOI: 10.1093/infdis/jiac349

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