Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone H2B ubiquitin ligase RNF20 is required for <i>MLL</i> -rearranged leukemia

14 Feb 2013

Abstract excerpt

Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L. Notably, interference with MLL-fusion cofactors like DOT1L is an emerging therapeutic strategy in this disease. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23412334
DOI: 10.1073/pnas.1301045110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone H2B ubiquitin ligase RNF20 is required for <i>MLL</i> -rearranged leukemiaPMID 23412334Read ↗

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integritySemantic proximity Read ↗

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological InterventionsSemantic proximity Read ↗

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Semantic proximity Read ↗

Targeting Epigenetic Programs in MLL-Rearranged LeukemiasSemantic proximity Read ↗

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL OncogenesSemantic proximity Read ↗

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.Semantic proximity Read ↗

The molecular biology of mixed lineage leukemiaSemantic proximity Read ↗

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genomeSemantic proximity Read ↗

Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemiaSemantic proximity Read ↗

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.Semantic proximity Read ↗

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesisSemantic proximity Read ↗

Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.