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Article

Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia

1 Oct 2021

Abstract excerpt

Acute myeloid leukemia (AML) with MLL-rearrangement (MLL-r) comprises ∼10% of all AML cases and portends poor outcomes. Much remains uncovered on how MLL-r AML drives leukemia development while preventing cells from normal myeloid differentiation. Here, we identified that transcription factor MEF2D is a super-enhancer-associated, highly expressed gene in MLL-r AML. Knockout of MEF2D profoundly impaired leukemia...

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PMID: 34597364
DOI: 10.1182/bloodadvances.2021004469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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