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Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer.

Mutagenesis - 1 Mar 2013

Mahjabeen Ishrat, Baig Ruqia Mehmood, Sabir Maimoona, Kayani Mahmood Akhtar

Abstract excerpt

The aetiology of head and neck cancer (HNC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are responsible for repair of DNA damage caused by reactive oxygen species and other electrophiles and therefore are good candidate susceptibility genes for HNC. Apurinic/apyrimidinic endonuclease-1 (APEX1) proteins have important...

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Source

Identifiers

PMID: 23408843
DOI: 10.1093/mutage/ges074

Genes

APEX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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