Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China.

doi:10.1002/jcla.22238

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Article

Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China.

Journal of clinical laboratory analysis - 1 Feb 2018

Lu Zhifang, Li Sisi, Ning Sisi, Yao Mengwei, Zhou Xunzhao, Wu Yuan, Zhong Changtao, Yan Kui, Wei Zhengbo, Xie Ying

Abstract excerpt

BACKGROUND: Apurinic/apyrimidinic endonuclease 1 (APEX1) plays a central role in the repair of oxidative DNA lesions via base excision repair, and polymorphism in the APEX1 gene may affect susceptibility to carcinogenesis. METHODS: Here, we assessed possible relationships between single-nucleotide polymorphism at APEX1 rs1760944 and risk of nasopharyngeal carcinoma (NPC) in 477 NPC patients and 558 healthy...

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PMID: 28464393
DOI: 10.1002/jcla.22238
PMCID: PMC6817270

Genes

APEX1

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