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Article

Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.

Science translational medicine - 13 Feb 2013

Titus Shiny, Li Fang, Stobezki Robert, Akula Komala, Unsal Evrim, Jeong Kyungah, Dickler Maura, Robson Mark, Moy Fred, Goswami Sumanta, Oktay Kutluk

Abstract excerpt

The underlying mechanism behind age-induced wastage of the human ovarian follicle reserve is unknown. We identify impaired ATM (ataxia-telangiectasia mutated)-mediated DNA double-strand break (DSB) repair as a cause of aging in mouse and human oocytes. We show that DSBs accumulate in primordial follicles with age. In parallel, expression of key DNA DSB repair genes BRCA1, MRE11, Rad51, and ATM, but not BRCA2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23408054
DOI: 10.1126/scitranslmed.3004925
PMCID: PMC5130338

Genes

ATM
BRCA1
MRE11
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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