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BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging1

30 Jul 2015

Abstract excerpt

Oocyte aging has a significant impact on reproductive outcomes both quantitatively and qualitatively. However, the molecular mechanisms underlying the age-related decline in reproductive success have not been fully addressed. BRCA is known to be involved in homologous DNA recombination and plays an essential role in double-strand DNA break repair. Given the growing body of laboratory and clinical evidence, we...

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PMID: 26224004
DOI: 10.1095/biolreprod.115.132290

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