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Article

BRCA Mutations and Fertility Preservation.

International journal of molecular sciences - 22 Dec 2023

Dias Nunes Joana, Demeestere Isabelle, Devos Melody

Abstract excerpt

Hereditary cancers mostly affect the adolescent and young adult population (AYA) at reproductive age. Mutations in BReast CAncer (BRCA) genes are responsible for the majority of cases of hereditary breast and ovarian cancer. BRCA1 and BRCA2 act as tumor suppressor genes as they are key regulators of DNA repair through homologous recombination. Evidence of the accumulation of DNA double-strand break has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38203374
DOI: 10.3390/ijms25010204
PMCID: PMC10778779

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