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Article

Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in mice

20 Nov 2020

Abstract excerpt

The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, the expression of most DNA BER genes, including APE1, OGG1, XRCC1, Ligase I, Ligase α, PCNA and...

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PMID: 33223510
DOI: 10.18632/aging.104123

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