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Primary oocytes with cellular senescence features are involved in ovarian aging in mice

13 Jun 2024

Abstract excerpt

In mammalian females, quiescent primordial follicles serve as the ovarian reserve and sustain normal ovarian function and egg production via folliculogenesis. The loss of primordial follicles causes ovarian aging. Cellular senescence, characterized by cell cycle arrest and production of the senescence-associated secretory phenotype (SASP), is associated with tissue aging. In the present study, we report that some...

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PMID: 38871781
DOI: 10.1038/s41598-024-64441-6

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