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The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging

25 Jun 2024

Abstract excerpt

Despite the advances in the understanding of reproductive physiology, the mechanisms underlying ovarian aging are still not deciphered. Recent research found an association between impaired ATM-mediated DNA double-strand break (DSB) repair mechanisms and oocyte aging. However, direct evidence connecting ATM-mediated pathway function decline and impaired oocyte quality is lacking. The objective of this study was...

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PMID: 38914566
DOI: 10.1038/s41420-024-02041-z

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