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Article

Ovarian Aging in Women With BRCA Germline Mutations

16 Aug 2017

Abstract excerpt

Context: Recent clinical and laboratory studies suggested that women with BRCA mutations have lower ovarian reserve and their primordial follicle oocytes may be more prone to DNA damage; however, direct proof is lacking. Objective: To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage. Design: A comparative laboratory study of ovarian...

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Identifiers

PMID: 28938488
DOI: 10.1210/jc.2017-00765

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