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Article

Impaired DNA Repair as a Mechanism for Oocyte Aging: Is It Epigenetically Determined?

Seminars in reproductive medicine - 1 Nov 2015

Titus Shiny, Stobezki Robert, Oktay Kutluk

Abstract excerpt

DNA damage is one of the most common insults that challenge all cells, and more so in resting cell-like oocytes. Increased DNA damage in aged oocyte has been shown to negatively impact the reproductive outcomes. The underlying molecular mechanism is still not completely comprehended, but based on the literature, this decline in the aging oocyte is attributed to impaired DNA repair and epigenetic modifications of...

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Identifiers

PMID: 26562289
DOI: 10.1055/s-0035-1567824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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