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BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging

14 Nov 2019

Abstract excerpt

BACKGROUND: Oocyte aging has significant clinical consequences, and yet no treatment exists to address the age-related decline in oocyte quality. The lack of progress in the treatment of oocyte aging is due to the fact that the underlying molecular mechanisms are not sufficiently understood. BRCA1 and 2 are involved in homologous DNA recombination and play essential roles in ataxia telangiectasia mutated...

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PMID: 31822904
DOI: 10.1093/humupd/dmz043

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