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Article

Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts.

Respiratory research - 14 Feb 2013

Larsson-Callerfelt Anna-Karin, Hallgren Oskar, Andersson-Sjöland Annika, Thiman Lena, Björklund Johan, Kron Josefine, Nihlberg Kristian, Bjermer Leif, Löfdahl Claes-Göran, Westergren-Thorsson Gunilla

Abstract excerpt

BACKGROUND: Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players in regulating the homeostasis of ECM proteins. The aim was to study the synthesis of prostacyclin and its effect on...

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Identifiers

PMID: 23406566
DOI: 10.1186/1465-9921-14-21
PMCID: PMC3585859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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