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Article

Altered fibroblast proteoglycan production in COPD.

Respiratory research - 11 May 2010

Hallgren Oskar, Nihlberg Kristian, Dahlbäck Magnus, Bjermer Leif, Eriksson Leif T, Erjefält Jonas S, Löfdahl Claes-Göran, Westergren-Thorsson Gunilla

Abstract excerpt

BACKGROUND: Airway remodeling in COPD includes reorganization of the extracellular matrix. Proteoglycans play a crucial role in this process as regulators of the integrity of the extracellular matrix. Altered proteoglycan immunostaining has been demonstrated in COPD lungs and this has been suggested to contribute to the pathogenesis. The major cell type responsible for production and maintenance of ECM...

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Identifiers

PMID: 20459817
DOI: 10.1186/1465-9921-11-55
PMCID: PMC2886021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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