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Article

Reversal of the Transcriptome by Prostaglandin E2 during Myofibroblast Dedifferentiation.

American journal of respiratory cell and molecular biology - 1 Jan 2016

Wettlaufer Scott H, Scott Jacob P, McEachin Richard C, Peters-Golden Marc, Huang Steven K

Abstract excerpt

Myofibroblasts, the major effector cells in pathologic fibrosis, derive from the differentiation of fibroblasts driven by mediators such as transforming growth factor-β1 (TGF-β1) and biomechanical signals. Although the myofibroblast has traditionally been considered a terminally differentiated cell, the lipid mediator prostaglandin E2 (PGE2) has been shown to not only prevent but also reverse myofibroblast...

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Identifiers

PMID: 26098591
DOI: 10.1165/rcmb.2014-0468OC
PMCID: PMC4742926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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