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Article

Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD

1 Dec 2008

Abstract excerpt

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The TGFbeta induced Smad pathway provides intracellular signals to regulate ECM production. We address the following hypothesis: fibroblasts have abnormal expression of genes in the Smad pathway in...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 19087346
DOI: 10.1186/1465-9921-9-83

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