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Article

Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung.

Journal of cellular and molecular medicine - 1 Jul 2012

Zhang Jing, Wu Lian, Qu Jie-ming, Bai Chun-xue, Merrilees Mervyn J, Black Peter N

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is characterized by loss of elastic fibres from small airways and alveolar walls, with the decrease in elastin increasing with disease severity. It is unclear why there is a lack of repair of elastic fibres. We have examined fibroblasts cultured from lung tissue from subjects with or without COPD to determine if the secretory profile explains lack of tissue repair. In...

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Identifiers

PMID: 22117690
DOI: 10.1111/j.1582-4934.2011.01492.x
PMCID: PMC3823220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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