Article

Differential collagen crosslinking and network organization creates distinct tissue remodeling patterns in fibrosis and COPD

2026-05-15

Abstract excerpt

Collagens are key components of the extracellular matrix (ECM) that play a crucial role in maintaining structure, strength, and function of the lungs. Fibrillar collagens are crosslinked by enzymes such as lysyl oxidases and transglutaminases and organized into networks by proteoglycans and glycoproteins. Collagens are the main load-bearing components and along with elastin may impart a non-linear strain hardening...

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Literature Corpus work: b5961648-025d-50de-989a-1495b2fbbacb
DOI: 10.64898/2026.05.13.724372

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