Altered cellular VEGF dynamics in Chronic Obstructive Pulmonary Disease

Abstract excerpt

Pulmonary vascular remodelling is common in patients with chronic obstructive pulmonary disease (COPD). Vascular endothelial growth factors (VEGFs) are key mediators in angiogenesis and vascular remodelling and exist in different isoforms. VEGF-A is the most potent angiogenic member binding to VEGF receptor 2 (VEGFR2). There are, however, few studies on other isoforms, as VEGF-C, and its receptor VEGFR3 in COPD an...

Topics

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• Gene Expression
• Hypertension, Pulmonary
• Neovascularization, Pathologic
• Pulmonary Alveoli
• Pulmonary Disease, Chronic Obstructive
• Reactive Nitrogen Species
• Receptors, Vascular Endothelial Growth Factor
• Vascular Endothelial Growth Factor A

Identifiers and source

Literature Corpus work

f6442276-8b8b-572d-98b5-29803075351d

DOI

10.64898/2026.05.04.722512